Solid-Phase Methodology for Synthesis of O-Alkylated Aromatic Oligoamide Inhibitors of α-Helix-Mediated Protein–Protein Interactions
نویسندگان
چکیده
Rapid access to rigid rods: A method is described for the synthesis of 3-O-alkylated aromatic oligobenzamide foldamers that could be used for assembly of libraries of α-helix mimetic inhibitors of protein-protein interactions (see scheme; Fmoc=9-fluorenylmethoxycarbonyl).
منابع مشابه
Solid-Phase Methodology for Synthesis ofO-Alkylated Aromatic Oligoamide Inhibitors of a-Helix-Mediated Protein–Protein Interactions
A major effort in modern bio-organic chemistry focuses on the design, synthesis and structural characterisation of foldamers: non-natural oligomers that adopt well-defined secondary, tertiary and quaternary structures. One ultimate objective of such studies is to recapitulate the functional behaviour of biomacromolecules. Particular emphasis has been placed on inhibitors of a-helix-mediated pro...
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